03 — The History
A compound decades in the making
From a 1939 isolation in Hokkaido to today's human trials, resveratrol has traveled through some of the most cited journals in modern science.
Japanese researcher Michio Takaoka first isolated resveratrol from the roots of white hellebore.
Researchers identified it in grapevines as a compound produced in response to stress.
Scientists proposed a link between red wine and the “French Paradox,” bringing resveratrol into public attention.
A study in Science reported that resveratrol showed activity in laboratory models of cellular processes, sparking major research interest.
Studies in Nature explored resveratrol's role in sirtuin pathways and healthspan in laboratory models.
Research continues on absorption, dosing, and human outcomes. Results in people are mixed, and more research is needed.
04 — Selected Research
The archive
Much of this research was conducted in laboratory or animal models. Human results vary.
Isolation of resveratrol from Veratrum grandiflorum
1939Takaoka M.
J. Faculty of Science, Hokkaido Imperial University
Wine, alcohol, platelets, and the French paradox
1992Renaud S, de Lorgeril M.
The Lancet
Cancer chemopreventive activity of resveratrol
1997Jang M, et al.
Science
Small molecule activators of sirtuins extend lifespan in yeast
2003Howitz KT, et al.
Nature
Resveratrol improves health and survival of mice on a high-calorie diet
2006Baur JA, et al.
Nature
High absorption but very low bioavailability of oral resveratrol in humans
2004Walle T, et al.
Drug Metabolism and Disposition
Our Approach
Absorption is a known challenge. That is why our R&D team focuses on formulation quality, delivery formats, and purity.